Endocrine Abstracts

TSH is the main regulator of the thyroid hormones (THs) synthesis/secretion, which in turn exert a negative feedback mechanism on the Tshb mRNA expression in the pituitary gland by reducing their transcription rate. Some of triiodothyronine (T3) effects are also shown in short period of time, characterizing the non genomic actions of THs. It has been shown previously that T3 acts on posttranscriptional steps of TSH synthesis and reduces its secre...